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You'll have to reinstall them. Simply reinstall the package. Do it as follows. I recommend you to remove the Windows 7 games before you installing a new build of Windows Once you upgrade the OS, install them again and continue to play. They will preserve your stats and scores. Winaero greatly relies on your support. You can help the site keep bringing you interesting and useful content and software by using these options:.

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Oh— By free templates we mean resume templates for MS Word that are entirely free to download and edit. Without even having to leave your email address anywhere. Pick a template, fill it in. Quick and easy. I love your resume. Good job guys, keep up the good work! Dylan My previous resume was really weak and I used to spend hours adjusting it in Word.

Click here to download it for free. Here's how to make a resume on Word :. The templates you see in the MS Word gallery work best with the documents whose content is almost identical to what you can see in the original sample. Here are some more examples from MS Word resume template gallery and other places around the web :. This two-column free Word resume template includes large section headings and bar charts to reflect your proficiency level. Pro Tip: Some Word resume templates allow you to include a photo.

However, adding pictures to resumes is rarely a good idea. This free modern resume template for Word is a good option for entry-level candidates with not too much experience under the belt. If you are looking for modern resume you can also check Modern Resume Template. This free resume template for Word will come in handy to fresh grads and experienced candidates alike. Plus, a great cover letter that matches your resume will give you an advantage over other candidates.

You can write it in our cover letter builder here. Here's what it may look like:. See more cover letter templates and start writing. This free creative resume template for Microsoft Word is suitable for less traditional industries that welcome originality and inventiveness. You may like to look at some Eye Catching Resume as well. You can also find some ideas other than Microsoft Word resume templates, for simple and clean resume designs here: Clean Resume. This free Word resume template is nicely divided into distinct resume parts.

The skills section has a visual bar graph that reflects your levels of proficiency. This is it! Would you like to share your opinion with us?

Leave us a comment below! See lists of good resume words action verbs, power words, adjectives, and synonyms to use instead of worn-out buzzwords like: team player, leadership, responsible for, communication, and lots more. Check which words to avoid on your resume and use that to land your dream job faster! Find our what you need to put on your resume and what recruiters are looking for.

Use these tips and examples to make a perfect resume. Use our 2, 5, and minute resume writing tips to quickly improve your resume. Actionable examples included. Read more! To learn more visit our Privacy Policy Got it! You can stop looking for the best resume templates for Word right now. You've just found them. The more you tell us the more we can help. Can you help us improve? Resolved my issue. Clear instructions. Easy to follow. No jargon. Pictures helped. Didn't match my screen.

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Microsoft used the most current virus-detection software that was available on the date that the file was posted. The file is stored on security-enhanced servers that help prevent any unauthorized changes to the file. For more information about a complete list of all released SP2 desktop packages , click the following article number to view the article in the Microsoft Knowledge Base:. This workbook lists the issues that are fixed by this service pack.

Note This workbook is available only in English. Known issues and behavior changes The following Microsoft Knowledge Base KB article describes a known issue or behavior change that occurs after you install this service pack:. Microsoft Office Service Pack 2 More Need more help? Expand your skills. Get new features first. Was this information helpful?

Yes No. Irakurri nola konfiguratu paketea instalatu ondoren. Note: This language is only available for Version or later and isn't compatible with Office Magbasa tungkol sa paraan ng pag-configure sa pack pagkatapos ng pag-i-install.

Karanta game da yanda ake tsara fakitin bayan girkawa. Funda malunga nendlela yokulungiselela iphekhi emva kokufakela. Funda ngendlela yokumisa iphekhi ngemva kokufaka.

Soma uko utunganya imikoreshereze y'ipaki nyuma yo kuyinjiza. Soma kuhusu jinsi ya kusanidi kifurushi baada ya kusakinisha. Aqra dwar kif tikkonfigura l-pakkett wara l-installazzjoni. Les om korleis du kan konfigurere pakken etter installering. Bala gore o ka rulaganya jang sephuthelo seno fa se sena go tsenngwa.

Paketni o'rnatgandan so'ng uni qanday sozlash haqida o'qing. After you install the language accessory pack, you must configure Office for your new language preferences. This configuration affects all your Office applications.

Note: If you're using Office and the commands available are different from what's shown here, click the Office tab and follow the instructions there. Under Office display Language , make sure the display language you want Office to use is listed.

Under Office authoring languages and proofing , make sure the language you want to use for authoring your document is listed. If the language accessory pack includes proofing tools for that language, its status appears as Proofing installed.

If the status is Proofing available , click the link to install the proofing tools. You can change the default language for all your Office applications in the Set the Office Language Preferences dialog. For more information, see Add a language or set language preferences in Office.

Table of contents. Office install. How to install Office. It features a simple interface with many customizable options:. Download multiple files at one time Download large files quickly and reliably Suspend active downloads and resume downloads that have failed. Yes, install Microsoft Download Manager recommended No, thanks. What happens if I don't install a download manager? Why should I install the Microsoft Download Manager? In this case, you will have to download the files individually.

You would have the opportunity to download individual files on the "Thank you for downloading" page after completing your download. Files larger than 1 GB may take much longer to download and might not download correctly. You might not be able to pause the active downloads or resume downloads that have failed. Details Note: There are multiple files available for this download. Once you click on the "Download" button, you will be prompted to select the files you need.

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Video Audio icon An illustration of an audio speaker. Audio Software icon An illustration of a 3. Software Images icon An illustration of two photographs. Images Donate icon An illustration of a heart shape Donate Ellipses icon An illustration of text ellipses. Microsoft Office Professional. EMBED for wordpress. Want more? Advanced embedding details, examples, and help!

Publication date Topics microsoft , office , , professional , , project , microsoft. Technet subscribers were given Microsoft license keys to use with the software but my uploads do not include license keys.

Microsoft terminated the Technet subscription programme in I hope these are useful for individuals or companies who have license keys and need to reinstall old but functional software rather than purchase new licenses. A guide to the filenames: - N edition: Satisfies a European Commission ruling by excluding bundled media software.

Download Summary:. Total Size: 0. Back Next. Microsoft recommends you install a download manager. Microsoft Download Manager. Manage all your internet downloads with this easy-to-use manager. It features a simple interface with many customizable options:. Download multiple files at one time Download large files quickly and reliably Suspend active downloads and resume downloads that have failed. Yes, install Microsoft Download Manager recommended No, thanks.

What happens if I don't install a download manager? Why should I install the Microsoft Download Manager? In this case, you will have to download the files individually. You would have the opportunity to download individual files on the "Thank you for downloading" page after completing your download. Files larger than 1 GB may take much longer to download and might not download correctly.

You might not be able to pause the active downloads or resume downloads that have failed. This white paper discusses the benefits of deploying Microsoft Office Service Pack 3 SP3 before upgrading to the Microsoft Office system, and details improvements to security and user experience. Details Note: There are multiple files available for this download. Once you click on the "Download" button, you will be prompted to select the files you need. File Name:. Microsoft Office Service Pack 3.

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For example, Active Directory will define a user by name, location, and department. With the added granularity of these attributes, IT teams are better equipped to track and manage important network objects. Beyond these categories, certain objects are designated as security principal objects , which can be assigned permissions or special authentication rules. IT teams use a unique SID security identifier to identify each security principal.

In Active Directory terms, a domain is an area of a network organized by a single authentication database. In other words, an Active Directory domain is essentially a logical grouping of objects on a network.

Domains are created so IT teams can establish administrative boundaries between different network entities. Active Directory domains are controlled by a tool called the domain controller. AD domains are usually identified via a domain name system DNS. One of your first considerations when setting up AD will be whether to use a single domain vs. In large networks, there might be dozens or even hundreds of Active Directory domains.

To organize them in a manageable way, domains are put together into groups called Active Directory domain trees. Enterprise networks with hundreds of users and thousands of network entities might have dozens and dozens of Active Directory trees. In such cases, IT teams will organize AD trees into groups called forests. Active Directory forests are the highest level of security boundary for network objects in the Active Directory tree and forest structure.

Within this Active Directory hierarchy, an AD forest is considered the most important logical container in an Active Directory configuration. This is because it contains all other users, domains, computers, group policies, and any other network objects of importance.

Although Active Directory may contain multiple domains and trees, most single Active Directory configurations only house a single domain forest. In multiple forest ecosystems, information and data exchange can only occur within the confines of a single Active Directory forest. This can be a challenge to manage, so IT admins should know creating more than one forest can make Active Directory monitoring practices significantly more complex. With an additional forest, IT teams can leverage an isolated copy of their AD system to test and tweak the configuration of their new software before rolling it out on a live network, minimizing the risk of the software affecting day-to-day operations.

Depending on the nature of the transaction, it can sometimes be easier to create an entirely new forest for the newly bought business, as opposed to migrating every user and resource over into your existing domains and trees. In such circumstances, an IT team can attempt to port the trees of the new division over to the existing forest, but this can quickly become complex.

Instead, leave the acquired network alone, and link the two Active Directory forests together by establishing a transitive trust authority. Although this solution has to be carried out manually, it can be effective. A transitive trust authority will extend the accessibility of resources, so the two forests can effectively merge on a logical level. This saves time and IT resources, which will likely already be stretched thin during a merger. IT teams can still manage the two Active Directory forests separately and let the trust link handle any mutual accessibility.

Windows NT environments were built as single master networks, meaning they used a single primary domain controller. With this setup, the primary domain controller was responsible for replicating any and all changes made to the backup domain controllers. If the primary domain controller was unavailable or experiencing downtime for some reason, no changes would be made to the domain database, which meant data was at risk of being lost or unaccounted for. This made Windows environments significantly less reliable, since IT teams had to take many manual steps to continually ensure changes could be made to a domain database or else risk losing valuable information.

To mitigate these risks, IT teams needed a software to deploy more than one domain controller. The solution came with the introduction of Active Directory, which, unlike Windows NT environments, was designed to be a scalable, distributed, replicated database.

This means AD operates with multiple domain controllers. Because every domain controller in an Active Directory ecosystem automatically creates a replica of the information it stores within its own domain, the entire AD system is more reliable than previous systems. Accordingly, Active Directory replication is best understood as a guarantee that any information or data processed by any of the domain controllers is consistent, updated, and synchronized.

The most common method to enable the domain and forest functional levels is to use the graphical user interface GUI administration tools that are documented in the TechNet article about Windows Server Active Directory functional levels. This article discusses Windows Server However, the steps are the same in the newer the operating system versions. Additionally, the functional level can be manually configured or can be configured by using Windows PowerShell scripts. For more information about how to manually configure the functional level, see the "View and set the functional level" section.

For more information about how to use Windows PowerShell script to configure the functional level, view Raise the Forest Functional Level. When you change the functional level attributes manually, the best practice is to make attribute changes on the Flexible Single Master Operations FSMO domain controller that is normally targeted by the Microsoft administrative tools.

When you increase the msDS-Behavior-Version attribute from the 0 value to the 1 value by usingAdsiedit. Some aspect of the modification is not permitted. The attributes on the partitions container and on the domain head are correctly increased. If an error message is report by the Ldp. To verify that the level increase was successful, refresh the attribute list, and then check the current setting. This error message may also occur after you have performed the level increase on the authoritative FSMO if the change has not yet replicated to the local domain controller.

After you connect to a domain controller, the RootDSE information for the domain controller appears. This information includes information on the forest, domain, and domain controllers. The following is an example of a Windows Server based domain controller. In the following example, assume that the domain mode is Windows Server and that the forest mode is Windows Server. The domain controller functionality represents the highest possible functional level for this domain controller.

You must change the domain mode to native mode before you raise the domain level if one of the following conditions is true:. If you do not change the domain mode to native mode before you raise the domain level, the operation is not completed successfully, and you receive the following error messages:.

When this process is used to raise the domain functional level to 2 Windows Server , the domain mode is automatically changed to native mode. The transition from mixed mode to native mode changes the scope of the Schema Administrators security group and the Enterprise Administrators security group to universal groups. When these groups have been changed to universal groups, the following message is logged in the System log:. When the Windows Server administrative tools are used to invoke the domain functional level, both the ntmixedmode attribute and the msdsBehaviorVersion attribute are modified in the correct order.

However, this does not always occur. In the following scenario, the native mode is implicitly set to a value of 0 without changing the scope for the Schema Administrators security group and the Enterprise Administrators security group to universal:.

Windows Server supports only mixed mode and native mode. Additionally, it only applies these modes to the domain functionality. The following sections list the Windows Server domain modes because these modes affect how Windows NT 4. There are many considerations when raising the operating system level of the domain controller.

These considerations are caused by the storage and replication limitations of the linked attributes in Windows Server modes. Domains that are upgraded from Windows NT 4. Windows Server domains maintain their current domain functional level when Windows Server domain controllers are upgraded to the Windows Server operating system. You can raise the domain functional level to either Windows Server native or Windows Server Windows Server Active Directory permits a special forest and domain functional level that is named Windows Server interim.

This functional level is provided for upgrades of existing Windows NT 4. Windows Server domain controllers are not supported in this mode. Windows Server interim applies to the following scenarios:. Windows Server interim provides two important enhancements while still permitting replication to Windows NT 4.

Because of the efficiencies in group replication that is activated in the interim level, the interim level is the recommended level for all Windows NT 4. See the "Best Practices" section of this article for more details. Windows Server interim can be activated in three different ways. The first two methods are highly recommended. The third option is less highly recommended because membership in security groups uses a single multi-valued attribute, which may result in replication issues.

The ways in which Windows Server interim can be activated are:. Before you upgrade the Windows NT 4. Upgrade to Microsoft Edge to take advantage of the latest features, security updates, and technical support.

Feedback will be sent to Microsoft: By pressing the submit button, your feedback will be used to improve Microsoft products and services. Privacy policy. In the organizational domain forest model, several autonomous groups each own a domain within a forest. Each group controls domain-level service administration, which enables them to manage certain aspects of service management autonomously while the forest owner controls forest-level service management.

The organizational domain forest model enables the delegation of authority for domain-level service management. The following table lists the types of service management that can be controlled at the domain level. Other types of service management, such as schema or replication topology management, are the responsibility of the forest owner. In an organizational domain forest model, domain owners are responsible for domain-level service management tasks.

Domain owners have authority over the entire domain as well as access to all other domains in the forest. For this reason, domain owners must be trusted individuals selected by the forest owner.




















N95, KN95, KF94 masks. GameStop PS5 in-store restock. Baby Shark reaches 10 billion YouTube views. Microsoft is done with Xbox One. Windows Windows. Most Popular. New Releases. Desktop Enhancements. Networking Software. Trending from CNET. Download Now. Developer's Description By Microsoft. Microsoft AutoRoute has the easy-to-use tools and customisable trip planning options to help you get there.

It includes maps for 37 European countries. It consists largely of toll roads, except around large cities and in parts of the north. It is a network worth of motorways. Full Specifications. What's new in version NET Framework 5. The Microsoft. NET Framework runtime and associated files that are required to run most client applications.

NET Framework is Microsoft's comprehensive and consistent … more info More Microsoft Silverlight 5. Silverlight is essentially nothing more than Microsoft's vision of a cross-browser, cross-platform plug-in designed to be the source of rich online user experiences and to dislodge Flash from its current dominant position on the market.

Descriptions containing microsoft autoroute Audio chipsets from Realtek are used in motherboards from many different manufacturers. If you have such a motherboard, you can use the drivers provided by Realtek.

More Microsoft Teams 1. Microsoft Teams is a platform developed by Microsoft that combines chat, meetings, notes and attachments. More Intel Processor Graphics More Microsoft.

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More UpdateStar Premium Edition UpdateStar 10 offers you a time-saving, one-stop information place for your software setup and makes your computer experience more secure and productive. Audio chipsets from Realtek are used in motherboards from many different manufacturers. If you have such a motherboard, you can use the drivers provided by Realtek. Adobe Flash Player ActiveX enables the display of multimedia and interactive content within the Internet Explorer web browser.




















Why should I install the Microsoft Download Manager? In this case, you will have to download the files individually. You would have the opportunity to download individual files on the "Thank you for downloading" page after completing your download. Files larger than 1 GB may take much longer to download and might not download correctly.

You might not be able to pause the active downloads or resume downloads that have failed. Microsoft Security Essentials provides real-time protection for your home or small business PC that guards against viruses, spyware, and other malicious software.

Details Note: There are multiple files available for this download. Once you click on the "Download" button, you will be prompted to select the files you need. File Name:. Date Published:. It means your PC has all updates and you don't have to install any other updates.

Version 21H1 is supported till Dec 13, I have the same question 7. Report abuse. Details required :. Cancel Submit.

Reza Ameri Volunteer Moderator. Does it display any error code? Have you tried performing any troubleshooting steps? What message are you seeing when you attempt to update? How satisfied are you with this reply? Thanks for your feedback, it helps us improve the site. Click Microsoft AntiSpyware and click Remove. You can reinstall Windows AntiSpyware Beta from the beta download page. The spyware scan removes sites added to Restricted Sites security zone in Internet Explorer.

If you have added Web sites to the Restricted Sites security zone to prevent access to them, we recommend you make a backup copy of the site list before running Windows AntiSpyware Beta. If you choose to remove such a program, Windows AntiSpyware Beta deletes the entire contents of the Program Files directory that relates to the P2P program.

Because some P2P programs store downloaded files in a default directory under Program Files, this might remove all files downloaded through the file-sharing program. For example, KaZaA stores. If you have installed any P2P file sharing programs, we recommend that you make a backup copy of your downloaded files before running Windows AntiSpyware Beta. You do not need to uninstall other anti-spyware or antivirus programs to run Windows AntiSpyware Beta.

I installed and un-installed MS Spyware in a matter of minutes. After initial reboot and program launch it did find a number of problems both Spybot and Pest Patrol missed; immediately after removing them IE stopped working. All is fine since uninstalling MS Spyware. Anyone else had that problem? I just downloaded this a couple of minutes ago and am already having problems with it.

Microsoft better improve things before they launch their new replacement for Windows. As of right now, Microsoft is convincing me to switch to a Mac. I am sick of dealing with all the patches and updates. Couldn,t agree with you more Kieth. I,ve had nothing but problems with spyware stormer. Just taken it off last night and so far no probs. I,m using spybot,adaware, and avg with kerio firewall and all seems hunky dory so far.

Got to agree about all the patches and updates Pc,s really are a pain. Unfortunately I have to run a Pc for some apps. Actually i had the problem with IE, not working properly. Which has probably been there for months or years!

And after all was working well. I run MS Antispyware and find nothing…or maybe 1 instance. I then run Ad-Aware by lavasoft and find As for MS Antispyware…well, they own enough of the computer industry. I have been using MS anti-spyware since its introduction. Can you install the new MS antispyware beta-1 on top of the beta, or does the beta have to be removed first?




















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Download PDF. Share Full Text for Free. Web of Science. Let us know here. System error. Please try again! How was the reading experience on this article? The text was blurry Page doesn't load Other:. Details Include any more information that will help us locate the issue and fix it faster for you.

Thank you for submitting a report! Submitting a report will send us an email through our customer support system. Submit report Close. One theme of the text is the use of artificial regressions for estimation, reference, and specification testing of nonlinear models, including diagnostic tests… Expand.

View via Publisher. Save to Library Save. Create Alert Alert. Share This Paper. Background Citations. Methods Citations. Results Citations. Citation Type. Has PDF. Publication Type. More Filters. The idea of using estimating functions goes a long way back, at least to Karl Pearson's introduction to the method of moments in It is now a very active area of research in the statistics … Expand. More Filters. The idea of using estimating functions goes a long way back, at least to Karl Pearson's introduction to the method of moments in It is now a very active area of research in the statistics … Expand.

Computer Science, Economics. Cointegration and Alternative Specifications. Econometric issues in forward-looking monetary models. Recently, single equation approaches for estimating structural models have become popular in the monetary economics literature. In particular, single-equation Generalized Method Moments estimators … Expand.

It is well known that standard asymptotic theory is not valid or is extremely unreliable in models with identification problems or weak instruments [Dufour , Econometrica , Staiger and Stock … Expand. The paper develops a general framework for identification, estimation, and hypothesis testing in cointegrated systems when the cointegrating coefficients are subject to possibly non-linear and … Expand. In testing nonnested or separate hypotheses, statistical practitioners typically use the j-test, due to Davidson and MacKinnon Estimation and Inference in Econometrics, Oxford University Press, New … Expand.

View 2 excerpts, cites methods. The issue of finite-sample inference in Generalised Autoregressive Conditional Heteroskedasticity GARCH -like models has seldom been explored in the theoretical literature, although its potential … Expand.

Chapter 8 Growth Econometrics.




















A train-shaped board book brings the new holiday movie, The Polar Express, to life for the youngest of fans. Includes tourist information, history, development of railroad and air travel, etc. The Art of The Polar Express celebrates the transformation of Chris Van Allsburg's celebrated children's book The Polar Express into a full-length, animated feature film through a fascinating collection of concept art, production storyboards, and computer-generated renderings.

Production designer Doug Chiang shares his original, never-before-seen artwork that evolved into the final motion picture. Weaving these pieces together are candid interviews with the star-studded cast and crew, including Robert Zemeckis and his team of filmmaking visionaries, that deliver rare insight into the film as they divulge the secrets behind their creative process.

Wanting to help a lost baby polar bear return home, Kiki Coral and her mermaid friends worry that the cost of the bear's transportation will prevent them from seeing a concert performance of their favorite boy band.

Simultaneous and eBook. Proceedings of the first International Scientific Meeting on the Polar Bear, held in Fairbanks, Alaska in , to report on the current state of knowledge of the biology, ecology and conservation needs of the polar bear Ursus maritimus in Alaska, Canada, Greenland, Scandinavia and the Soviet Union. This beautiful, collectible souvenir folio features eight pages of more than 30 full-color scenes from the film.

A mysterious train. An amazing journey. A night you'll never forget. Believing in Father Christmas isn't easy when all of your friends and family insist he's just make-believe. The bad Santa experience has sent shockwaves through the family. Her feelings of disappointed escalated when Melissa saw pictures her friends had posted from their own Polar Express experiences.

It was a million miles away from what we got. The railway advertises the experience as 'an immersive re-creation inspired by the Polar Express film 'where customers can 'embrace the spirit of Christmas on their wonder-filled trip' and 'take home lasting memories of a magical experience'. Some parents commented on Melissa's Facebook post in support of her scathing review, saying they too were disappointed after booking the same 'expensive experience' and coming away with children 'sceptical' about Santa.

One parent said: "I'm so glad I'm not the only person to say this! I was mortified!! Advanced embedding details, examples, and help!

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Try the modernized ClinicalTrials. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Explore , research studies in all 50 states and in countries. Find a study all fields optional Saved Studies. Recruiting and not yet recruiting studies All studies. If you choose to participate, you must go through our informed consent process, where you will learn key facts about the study.

You'll have plenty of time to ask questions, and the research team will walk you through details like: why they are doing the study, possible risks and benefits, how long it will last and the needed tests. This process will continue throughout the study.

It is not a contract. You can always ask questions, and you will always be able to leave the study at any time for any reason. King: Like existing vaccines against seasonal influenza, FluMos-v1 Table 1 is meant to create antibodies to several different influenza virus strains. Unlike existing influenza shots, the new vaccine uses a mosaic nanoparticle immunogen that co-displays antigens from multiple influenza viruses on the same nanoparticle surface.

In our pre-clinical work, we found that the nanoparticle immunogen elicited a greater diversity of protective antibodies than did current vaccines against influenza. We are particularly interested in learning about how the vaccine will interact with immune systems that have encountered influenza viruses or vaccines before.

Despite this setback, the full results are not yet out and are critically important. The trial results will be a first real look at fundamental aspects of RNA-lowering strategies, including how the drug impacted various biomarkers across hundreds of participants. The results could transform the clinical-trial landscape for other conditions treatable by ASOs. Julian Gillmore: I have been looking after patients with transthyretin amyloidosis for 25 years, and until 5 years ago, I just watched their health decline.

Some years ago, gene silencers became available and improved outcomes for patients, which was a very substantial advance. Preliminary data from this trial have shown for the first time that CRISPR-based gene therapies can be administered by intravenous infusion to edit a specific gene in liver cells.

Full results are expected next year. This new gene-editing therapy offers patients the prospect of meaningful clinical improvements after a single dose of the drug. Julian Gillmore is a reader in medicine and an honorary consultant nephrologist at Royal Free London Hospital.

This trial tests new combination regimens of miltefosine and paromomycin in Ethiopia, Sudan, Kenya and Uganda in eastern Africa. The aim is to replace the toxic sodium stibogluconate component of the current injectable treatment for kala-azar with the orally administered miltefosine.

This is a much-needed improvement patients have been waiting for and we have been working toward for years, as oral treatments can be administered at local health centers, closer to affected communities.

Patients diagnosed with kala-azar will die if they are not treated. The new, less toxic and more easily administered regimen will also be good for children, who are disproportionately affected by visceral leishmaniasis.

Blair Leavitt: There are several ongoing studies of pridopidine that target disease progression in neurodegenerative disorders. Pridopidine is an oral small-molecule therapeutic that selectively targets the sigma 1 receptor and has a well-established safety record from previous human clinical trials. Kevin M. Flanigan: A small number of boys with Duchenne muscular dystrophy have a disease caused by a duplication of exon 2 of the DMD gene which encodes dystrophin. This exon duplication can be removed through the use of an adeno-associated virus 9—based vector, which carries copies of the non-coding small nuclear RNA U7 with a sequence directed toward splice donor and acceptor sites within the duplicated exon.

This exon-skipping approach is a first in-human trial and results in exclusion of a copy of DMD exon 2, and expression of the full-length, wild-type dystrophin. Preliminary data have been presented showing successful expression, for the first time, of full-length dystrophin in response to this viral gene therapy.

There are four more gene therapies for Duchenne muscular dystrophy being tested, but each of these requires delivery of a gene encoding an engineered microdystrophin, which is not present in nature and which is expected to result in substantial functional improvement.

David Nutt: Psilocybin, a psychedelic derived from fungi, is showing great promise in the treatment of mental-health conditions. First, it tackles the huge problem of depression that is resistant to existing treatments.

Finally, it will also give some readouts on the dose—effect relationship, as they are testing three greatly differing doses of psilocybin, at 1 mg, 10 mg and 25 mg.